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Sparsentan 400mg Tablets

Sparsentan 400mg Tablets

400mg Tablets, Bottle

4.5 (154)

₹39,000

Sparsentan 400mg Tablets is a dual endothelin and angiotensin II receptor antagonist used to treat IgA nephropathy and focal segmental glomerulosclerosis. It works by blocking both receptor pathways to reduce intraglomerular pressure, inflammation, and fibrosis, effectively lowering proteinuria. Common side effects include hypotension, peripheral edema, and dizziness. Regular monitoring of blood pressure, renal function, and potassium levels is recommended during treatment.

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Description

Sparsentan 400mg Tablets

Information Sparsentan is an orally administered dual endothelin receptor and angiotensin II receptorantagonist developed for proteinuric kidney diseases.

Mechanism of Action Sparsentan reduces intraglomerular pressure and proteinuria.- Blocks endothelin type A receptors- Antagonizes angiotensin II type 1 receptors- Reduces glomerular inflammation and fibrosis

Uses / Indications Used in nephrology practice.- IgA nephropathy- Focal segmental glomerulosclerosis

Side Effects Generally related to blood pressure reduction.- Hypotension- Peripheral edema- Dizziness

Warnings & Precautions Monitoring is required.- Monitor blood pressure regularly- Assess renal function and potassium levels

Conclusion Sparsentan offers dual pathway blockade for effective reduction of proteinuria in kidneydisease.This information is intended for educational purposes only and should not replace clinicaljudgment. Treatment decisions must be made by qualified healthcare professionals.

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Category
Info Table
Strength 400 mg
Pack Size 30 Tablets
Brand Luciseta
Composition Sparsentan
Form Tablets
Packaging Type Bottle
Manufacturer Lucius Pharma
Vendor Info
Benefits
Reviews

Description

Sparsentan 400mg Tablets

Information Sparsentan is an orally administered dual endothelin receptor and angiotensin II receptorantagonist developed for proteinuric kidney diseases.

Mechanism of Action Sparsentan reduces intraglomerular pressure and proteinuria.- Blocks endothelin type A receptors- Antagonizes angiotensin II type 1 receptors- Reduces glomerular inflammation and fibrosis

Uses / Indications Used in nephrology practice.- IgA nephropathy- Focal segmental glomerulosclerosis

Side Effects Generally related to blood pressure reduction.- Hypotension- Peripheral edema- Dizziness

Warnings & Precautions Monitoring is required.- Monitor blood pressure regularly- Assess renal function and potassium levels

Conclusion Sparsentan offers dual pathway blockade for effective reduction of proteinuria in kidneydisease.This information is intended for educational purposes only and should not replace clinicaljudgment. Treatment decisions must be made by qualified healthcare professionals.

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Frequently Asked Questions

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What is Sparsentan 400mg Tablet used for?
Sparsentan 400mg Tablet is an orally administered dual endothelin receptor and angiotensin II receptor antagonist developed for proteinuric kidney diseases, specifically IgA nephropathy and focal segmental glomerulosclerosis (FSGS).
It blocks endothelin type A receptors and antagonizes angiotensin II type 1 receptors simultaneously, reducing intraglomerular pressure, glomerular inflammation, and fibrosis — this dual pathway blockade effectively lowers protein loss in the urine (proteinuria).
Sparsentan carries a warning about potential liver damage. Your doctor will order a blood test before you start treatment, monthly during the first 12 months, and every 3 months after that. Stop taking it and contact your doctor immediately if you experience extreme tiredness, upper right stomach pain, nausea, vomiting, or loss of appetite.
Common side effects are generally related to blood pressure reduction, including hypotension (low blood pressure), peripheral edema (swelling), and dizziness.
Beyond liver function, regular monitoring of blood pressure, renal function, and potassium levels is recommended throughout treatment to catch any imbalances early.
No. As a specialized nephrology medicine with a liver-related warning, Sparsentan requires a valid prescription and close medical supervision with regular lab monitoring.

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