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Sparsentan 200mg Tablets

Sparsentan 200mg Tablets

200mg Tablets, Bottle

4.5 (154)

₹34,600

Sparsentan 200mg Tablets is used for dose titration in proteinuric kidney disorders, including IgA nephropathy and chronic kidney disease. It works by blocking endothelin-mediated vasoconstriction and angiotensin II signaling, helping protect the kidney’s glomerular structure and reduce protein loss. Common side effects include hypotension, edema, and fatigue. Careful dose titration and regular monitoring of renal function are recommended, and it should be avoided during pregnancy.

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Description

Sparsentan 200mg Tablets

Information Sparsentan 200 mg is a lower-dose formulation used for dose titration in proteinuric kidneydisorders.

Mechanism of Action Sparsentan modulates renal hemodynamics.- Inhibits endothelin-mediated vasoconstriction- Blocks angiotensin II signaling- Protects glomerular structure

Uses / Indications Used under nephrology supervision.- IgA nephropathy- Proteinuric chronic kidney disease

Side Effects Dose-related effects may occur.- Hypotension- Edema- Fatigue

Warnings & Precautions Careful titration advised.- Monitor renal parameters- Avoid use in pregnancy

Conclusion Lower-dose Sparsentan allows safer initiation while maintaining renal protective effects.This information is intended for educational purposes only and should not replace clinicaljudgment. Treatment decisions must be made by qualified healthcare professionals.

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Category
Info Table
Strength 200 mg
Pack Size 30 Tablets
Brand Luciseta
Composition Sparsentan
Form Tablets
Packaging Type Bottle
Manufacturer Lucius Pharma
Vendor Info
Benefits
Reviews

Description

Sparsentan 200mg Tablets

Information Sparsentan 200 mg is a lower-dose formulation used for dose titration in proteinuric kidneydisorders.

Mechanism of Action Sparsentan modulates renal hemodynamics.- Inhibits endothelin-mediated vasoconstriction- Blocks angiotensin II signaling- Protects glomerular structure

Uses / Indications Used under nephrology supervision.- IgA nephropathy- Proteinuric chronic kidney disease

Side Effects Dose-related effects may occur.- Hypotension- Edema- Fatigue

Warnings & Precautions Careful titration advised.- Monitor renal parameters- Avoid use in pregnancy

Conclusion Lower-dose Sparsentan allows safer initiation while maintaining renal protective effects.This information is intended for educational purposes only and should not replace clinicaljudgment. Treatment decisions must be made by qualified healthcare professionals.

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Frequently Asked Questions

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What is Sparsentan 200mg Tablet used for?
Sparsentan is used for dose titration in proteinuric kidney disorders, primarily IgA nephropathy (IgAN), to slow kidney function decline in adults at risk of disease progression. It’s also used off-label in some proteinuric chronic kidney disease cases. Treatment is managed exclusively under nephrology supervision and requires enrollment in a restricted access program before it can even be dispensed.
Sparsentan blocks both endothelin-mediated vasoconstriction and angiotensin II signaling simultaneously, which is unusual — most kidney-protective drugs target only one pathway. This dual action helps protect the kidney’s glomerular filtering structure and reduces protein loss in urine, potentially slowing the long-term decline in kidney function seen in IgAN.
Sparsentan 200mg is used as a titration dose — treatment typically starts at 200mg once daily for 14 days, then increases to 400mg once daily if tolerated. Any restart after an interruption may require re-titration from a lower dose rather than resuming the previous dose directly, so don’t self-adjust.
Liver function blood tests are required before starting treatment, monthly for the first 12 months, then every 3 months thereafter — this is a strict FDA-mandated schedule, not a general recommendation. Kidney function is also monitored regularly. Treatment may be paused or stopped if liver test results become abnormal.
Common effects include hypotension, fluid retention (edema), fatigue, dizziness, elevated potassium, and anemia. Sparsentan carries an FDA boxed warning for liver toxicity — watch for jaundice, dark urine, nausea, or fatigue and contact your doctor immediately. It’s dispensed only through the FDA-mandated FILSPARI REMS restricted-access program, not through standard prescriptions.
No — it’s contraindicated in pregnancy due to a high risk of serious birth defects or fetal loss. A negative pregnancy test is required before starting, effective contraception is mandatory during treatment and for two weeks after stopping, and any missed period or suspected pregnancy must be reported to your doctor immediately.

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