Description
Introduction Of Cometriq 100mg Capsules:
Cometriq 100mg Capsules contain cabozantinib, a kinase inhibitor used in the treatment of progressive, metastatic medullary thyroid cancer (MTC). Cometriq capsules are supplied as a combination of one 80 mg capsule and one 20 mg capsule, providing a total daily dose of 100 mg.
The product shown is the 100 mg Daily Dose Blister Card presentation of Cometriq, manufactured for Exelixis, Inc. Each blister card provides a 7-day supply, and the 28-day presentation contains 4 blister cards with a total of 56 capsules.
Uses Of Cometriq 100mg Capsule:
Cometriq is used for:
- Treatment of progressive medullary thyroid cancer (MTC).
- Treatment of MTC that has spread to other parts of the body (metastatic disease).
- Helping slow the growth and progression of certain medullary thyroid cancer tumors.
- In some patients, treatment may also result in reduction in tumor size.
Cometriq is an anticancer medicine and should be used only under the supervision of an oncologist or other qualified healthcare professional.
Benefits Of Cometriq 100mg Capsules:
- Helps inhibit tumor growth: Cabozantinib blocks signaling pathways involved in the growth and spread of cancer cells.
- Helps control metastatic MTC: It is specifically indicated for progressive, metastatic medullary thyroid cancer.
- Targets multiple kinase pathways: Cabozantinib acts on several receptor tyrosine kinases involved in tumor growth, blood-vessel formation and cancer progression.
- May reduce tumor size: Clinical studies have shown that some patients experience tumor shrinkage during treatment.
Side Effects Of Cometriq 100mg Capsules:
Common side effects associated with Cometriq may include:
- Diarrhea
- Mouth sores or stomatitis
- Decreased appetite
- Weight loss
- Nausea
- Vomiting
- Fatigue
- Abdominal pain
- Constipation
- Changes in taste
Cometriq can also cause serious adverse effects, including severe bleeding, gastrointestinal perforation or fistula, blood clots, impaired wound healing, severe hypertension, cardiac problems, proteinuria, osteonecrosis of the jaw, and reversible posterior leukoencephalopathy syndrome. Patients should be closely monitored during treatment.
Mechanism Of Action Of Cometriq 100mg Capsules:
Cabozantinib is a tyrosine kinase inhibitor that blocks the activity of several receptor tyrosine kinases involved in cancer-cell growth, tumor progression and the development of blood vessels supplying tumors.
By inhibiting these signaling pathways, cabozantinib can slow the growth and spread of cancer cells and interfere with tumor-associated blood-vessel formation. This mechanism contributes to its anticancer activity in progressive, metastatic medullary thyroid cancer.

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